5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine
CAS No.:86318-86-7
Molecular Formula:C₄₂H₄₁N₅O₈
Molecular Weight:743.816
Hs Code.:

5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N<sup>6</sup>-benzoyl-D-adenosine

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 102490-50-6
2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

: 86318-86-7
5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2005.07.026

Reference yield:

: 79154-57-7
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

: 86318-86-7
5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 20 °C

2: 0.70 g / tetrabutylammonium fluoride / CHCl₃; tetrahydrofuran / 0.17 h

3: 92.3 percent / pyridine / 2 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.tetasy.2005.07.026

Reference yield:

: 87865-81-4
N-{9-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(tetrahydro-furan-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide

: 86318-86-7
5'-O-(4,4'-dimethoxytrityl)-2'-O-tetrahydrofuran-2-yl-N⁶-benzoyl-D-adenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 0.70 g / tetrabutylammonium fluoride / CHCl₃; tetrahydrofuran / 0.17 h

2: 92.3 percent / pyridine / 2 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform;
DOI:10.1016/j.tetasy.2005.07.026