(S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide

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Chemical Name:(S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide
CAS No.:1312411-00-9
Molecular Formula:C₂₈H₃₂N₄O₄S
Molecular Weight:520.652
Hs Code.:

Synonyms:(S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide

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Chemical Property of (S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide

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Technology Process of (S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide

There total 11 articles about (S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312304-18-9
[1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

: 1312411-00-9
(S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

: 151978-50-6
N-(tert-butoxycarbonyl)-pent-4-ynyl-1-amine

: 1312411-00-9
(S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C / Ice/water bath

1.2: 72 h

2.1: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

3.1: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

4.1: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / 20 °C

5.2: 24 h / 20 °C

6.1: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h / 20 °C

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 19718-49-1
4-amino-3-iodobenzoic acid methyl ester

: 1312411-00-9
(S)-2-(3-(2-amino-N-methyl-3-(thiophen-2-yl)propanamido)propyl)-N-(3,4-dimethoxyphenyl)-1H-indole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; lithium hydroxide / methanol / 20 h / Inert atmosphere; Reflux

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 24 h / 20 °C

3.1: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

4.1: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

5.1: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / 20 °C

6.2: 24 h / 20 °C

7.1: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h / 20 °C

With hydrogenchloride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; lithium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;