[1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester
CAS No.:1312304-18-9
Molecular Formula:C₃₃H₄₀N₄O₆S
Molecular Weight:620.77
Hs Code.:

Synonyms:[1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

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Chemical Property of [1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

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Technology Process of [1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

There total 10 articles about [1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56675-37-7
(S)-2-tert-butoxycarbonylamino-3-thiophen-2-yl-propionic acid

: 1312304-17-8
2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

: 1312304-18-9
[1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

Guidance literature:: 2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

(S)-2-tert-butoxycarbonylamino-3-thiophen-2-yl-propionic acid; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 151978-50-6
N-(tert-butoxycarbonyl)-pent-4-ynyl-1-amine

: 1312304-18-9
[1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C / Ice/water bath

1.2: 72 h

2.1: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

3.1: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

4.1: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / 20 °C

5.2: 24 h / 20 °C

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 19718-49-1
4-amino-3-iodobenzoic acid methyl ester

: 1312304-18-9
[1-({3-[5-(3,4-Dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]propyl}-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-(S)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; lithium hydroxide / methanol / 20 h / Inert atmosphere; Reflux

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 24 h / 20 °C

3.1: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

4.1: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

5.1: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / 20 °C

6.2: 24 h / 20 °C

With hydrogenchloride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; lithium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;