(S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

Base Information

Chemical Name:(S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate
CAS No.:1401468-86-7
Molecular Formula:C₂₂H₂₂Br₂N₂O₄
Molecular Weight:538.236
Hs Code.:

Synonyms:(S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

Suppliers and Price of (S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

There total 2 articles about (S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 936242-42-1
(S)-2-((tert-butoxycarbonyl)amino)-4-pentynoic acid benzyl ester

: 1214383-75-1
3,5-dibromo-4-iodopyridine

: 1401468-86-7
(S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃; for 15h; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tetlet.2012.08.084

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1401468-86-7
(S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -85 °C / Inert atmosphere; Molecular sieve

1.2: 4 h / -78 °C / Inert atmosphere; Molecular sieve

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere; Molecular sieve

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; n-butyllithium; trifuran-2-yl-phosphane; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: |Negishi Coupling / 1.2: |Negishi Coupling / 2.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tetlet.2012.08.084

Reference yield: 60.0%

: 1401468-86-7
(S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate

: 119768-48-8
(S)-2-((tert-butoxycarbonyl)amino)-4-iodobutyric acid benzyl ester

: 1401468-88-9
C₃₈H₄₄BrN₃O₈

: 1401468-84-5
((2S,2'S)-benzyl 4,4'-(4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonyl amino)-5-oxopent-1-ynyl)pyridine-3,5-diyl)bis(2-(tert-butoxycarbonylamino)butanoate))

Guidance literature:: (S)-2-N-tert-butoxycarbonylamino-4-iodo-butanoic acid benzyl ester; With chloro-trimethyl-silane; zinc; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere; Molecular sieve;

(S)-benzyl 2-(tert-butoxycarbonylamino)-5-(3,5-dibromopyridin-4-yl)pent-4-ynoate; With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; In N,N-dimethyl-formamide; at 40 - 50 ℃; for 24h; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tetlet.2012.08.084