acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

Base Information

Chemical Name:acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester
CAS No.:1290630-23-7
Molecular Formula:C₂₆H₂₆ClNO₁₀
Molecular Weight:547.946
Hs Code.:

Synonyms:acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

Suppliers and Price of acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

There total 14 articles about acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290629-73-0
acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

: 1290630-23-7
acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

Guidance literature:: acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester; With nitric acid; In dichloromethane; water;

With tetrabutylammomium bromide; In dichloromethane; water; at 20 ℃;

Reference yield:

: 461432-26-8,1373321-04-0
dapagliflozin

: 1290630-23-7
acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 18 h / 0 °C / Reflux

2.1: sodium methylate / methanol / 0 - 45 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 18 h / 20 °C

4.1: diethylzinc / hexane; diethyl ether / 8 h / 20 - 40 °C

5.1: hydrogenchloride; hydrogen; water / palladium 10% on activated carbon / methanol / 18 h / 20 °C

6.1: dmap; pyridine / dichloromethane / 20 °C

7.1: boron tribromide / dichloromethane / -78 - -15 °C

8.1: nitric acid / dichloromethane; water

8.2: 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; water; hydrogen; iodine; diethylzinc; nitric acid; sodium methylate; boron tribromide; sodium hydride; triphenylphosphine; palladium 10% on activated carbon; In methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1219000-72-2
(2S,3R,4R,5S,6S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(iodomethyl)tetrahydro-2H-pyran-3,4,5-triol

: 1290630-23-7
acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 0 - 45 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.2: 18 h / 20 °C

3.1: diethylzinc / hexane; diethyl ether / 8 h / 20 - 40 °C

4.1: hydrogenchloride; hydrogen; water / palladium 10% on activated carbon / methanol / 18 h / 20 °C

5.1: dmap; pyridine / dichloromethane / 20 °C

6.1: boron tribromide / dichloromethane / -78 - -15 °C

7.1: nitric acid / dichloromethane; water

7.2: 20 °C

With pyridine; hydrogenchloride; dmap; water; hydrogen; diethylzinc; nitric acid; sodium methylate; boron tribromide; sodium hydride; palladium 10% on activated carbon; In methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide;