1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

Base Information

Chemical Name:1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline
CAS No.:159819-93-9
Molecular Formula:C₂₀H₂₁NO₄S
Molecular Weight:371.457
Hs Code.:

Synonyms:1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

Suppliers and Price of 1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

There total 5 articles about 1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 124-63-0
methanesulfonyl chloride

: 159819-89-3
1,2-Dihydro-3-hydroxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

: 159819-93-9
1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jm00016a014

Reference yield:

: 152818-34-3
1,2-dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolinecarboxylic acid

: 159819-93-9
1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl₂)2, DMF / tetrahydrofuran / 0.5 h / Ambient temperature

2: NaBH₄ / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.25 h / 0 °C

3: 79 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With sodium tetrahydroborate; (COCl₂)2; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00016a014

Reference yield:

: 152818-36-5
2-benzoyl-4,5-dimethylbenzoic acid

: 159819-93-9
1,2-Dihydro-3-methanesulfonyloxymethyl-2,6,7-trimethyl-1-oxo-4-phenylisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) K₂CO₃, 2.) AcOH, conc. HCl / 1.) acetone, DMF, RT, 60 h, 2.) 110 deg C, 5 h

2: 2.) 4 N HCl / 1.) MeOH, RT, 2 h, 2.) EtOAc, RT, 2 h

3: (COCl₂)2, DMF / tetrahydrofuran / 0.5 h / Ambient temperature

4: NaBH₄ / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.25 h / 0 °C

5: 79 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; (COCl₂)2; potassium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00016a014