(1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester
• CAS No.: 331961-39-8
• Molecular Formula: C₁₇H₃₂O₃
• Molecular Weight: 284.439

Synonyms:(1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester

Chemical Property of (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester

There total 11 articles about (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methanol (67-56-1) + 1-[(1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexyl]-ethanone (331961-37-6) → (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester (331961-39-8)

Guidance literature:

With sodium bromide; at 0 ℃; for 0.75h; Electrochemical reaction;

DOI:10.1002/1521-3765(20010119)7:2<520::AID-CHEM520>3.0.CO;2-5

Reference yield:

(6R,5R)-2,6-dimethyl-5-(1-methylethenyl)-2-cyclohexen-1-one (91840-35-6) → (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester (331961-39-8)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 70 percent / aq. NaHCO₃; sodium dithionite / Adogen 464 / toluene / 2 h / Heating

2.1: EtMgBr / toluene; tetrahydrofuran / 0 - 60 °C

2.2: toluene; tetrahydrofuran / 2 h / Heating

2.3: 51 percent / aq. H₂SO₄ / tetrahydrofuran / 10 h

3.1: Mg; methanol

4.1: LiAlH₄ / tetrahydrofuran

5.1: O₃ / CH₂Cl₂; methanol / 0 °C

5.2: dimethylsulfide / CH₂Cl₂; methanol

6.1: trimethylorthoformate; p-TsOH

7.1: Et₃N; DMAP / CH₂Cl₂

8.1: NaH / dimethylsulfoxide

8.2: dimethylsulfoxide; tetrahydrofuran

9.1: H₂ / 5percent Rh/Al₂O₃ / ethyl acetate

10.1: aq. pyridinium p-toluenesulfonate / Heating

11.1: 76 percent / NaBr / 0.75 h / 0 °C / Electrochemical reaction

With methanol; dmap; lithium aluminium tetrahydride; sodium dithionite; ethylmagnesium bromide; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; ozone; magnesium; triethylamine; sodium bromide; trimethyl orthoformate; adogen 464; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;

DOI:10.1002/1521-3765(20010119)7:2<520::AID-CHEM520>3.0.CO;2-5

Reference yield:

Ethyl [(Z,2R,3R,6R)-2,6-dimethyl-3-isopropenylcyclohexylidene]acetate (331961-19-4) → (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester (331961-39-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: Mg; methanol

2.1: LiAlH₄ / tetrahydrofuran

3.1: O₃ / CH₂Cl₂; methanol / 0 °C

3.2: dimethylsulfide / CH₂Cl₂; methanol

4.1: trimethylorthoformate; p-TsOH

5.1: Et₃N; DMAP / CH₂Cl₂

6.1: NaH / dimethylsulfoxide

6.2: dimethylsulfoxide; tetrahydrofuran

7.1: H₂ / 5percent Rh/Al₂O₃ / ethyl acetate

8.1: aq. pyridinium p-toluenesulfonate / Heating

9.1: 76 percent / NaBr / 0.75 h / 0 °C / Electrochemical reaction

With methanol; dmap; lithium aluminium tetrahydride; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; ozone; magnesium; triethylamine; sodium bromide; trimethyl orthoformate; 5percent Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1002/1521-3765(20010119)7:2<520::AID-CHEM520>3.0.CO;2-5

upstream raw materials:

methanol

1-[(1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexyl]-ethanone

(6R,5R)-2,6-dimethyl-5-(1-methylethenyl)-2-cyclohexen-1-one

(2R,3R,6R)-2,6-dimethyl-3-(prop-1-en-2-yl)cyclohexan-1-one

Downstream raw materials:

(1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarbaldehyde

6-((1S,2S,3R,6R)-3-Hydroxymethyl-2,6-dimethyl-cyclohexyl)-2-methyl-hexan-2-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 331961-39-8 (1R,2S,3S,4R)-3-(5-Hydroxy-5-methyl-hexyl)-2,4-dimethyl-cyclohexanecarboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send