tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

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Chemical Name:tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate
CAS No.:1393901-43-3
Molecular Formula:C₃₁H₃₅F₃N₄O₅
Molecular Weight:600.638
Hs Code.:

Synonyms:tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

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Chemical Property of tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

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Technology Process of tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

There total 16 articles about tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1002726-96-6
2-(4-aminophenyl)morpholine-4-carboxylic acid tert-butyl ester

: 1393901-29-5
methyl 2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1393901-43-3
tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

Guidance literature:: With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 100 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1393901-43-3
tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate; methanol / 3 h / 20 °C / Cooling with ice

1.2: 16 h / 20 °C

2.1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 1,4-dioxane / 4 h / 90 °C

3.1: sodium hydride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 17 h / 20 °C / Cooling with ice

4.1: hydrogen bromide; acetic acid; phenol / 12 h / 75 °C / sealed tube; microwave irradiation

5.1: dmap / dichloromethane / 1 h

6.1: hydrazine hydrate / iron(III) chloride hexahydrate / methanol / 5 h / Reflux

6.2: 7 h / Reflux

7.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

With methanol; sodium tetrahydroborate; hydrazine hydrate; N-benzyl-N,N,N-triethylammonium chloride; hydrogen bromide; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid; phenol; dmap; iron(III) chloride hexahydrate; In 1,4-dioxane; methanol; dichloromethane; 2,2,2-trifluoroethanol;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393901-43-3
tert-butyl 2-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.17 h / 100 °C / microwave irradiation

7: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;