5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester

Base Information

• Chemical Name: 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester
• CAS No.: 866930-31-6
• Molecular Formula: C₂₃H₁₄ClNO₂S
• Molecular Weight: 403.889
• Mol file: 866930-31-6.mol

Synonyms:5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester

Chemical Property of 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester

There total 1 articles about 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-(4-chloro-phenyl)-2-ethynyl-pyridine (690264-31-4) + methyl 5-iodobenzo[b]thiophene-2-carboxylate (146137-90-8) → 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester (866930-31-6)

Guidance literature:

With triethylamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 20 ℃; for 70h;

Reference yield: 93.0%

5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester (866930-31-6) → 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid (866930-32-7)

Guidance literature:

5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester; With sodium hydroxide; ethanol; at 20 ℃;

With hydrogenchloride; at 0 ℃; pH=6;

Reference yield: 93.0%

5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester (866930-31-6) + ethanol (64-17-5) → 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid (866930-32-7)

Guidance literature:

5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid methylester; ethanol; With sodium hydroxide; at 20 ℃;

With hydrogenchloride; In water; pH=6;

upstream raw materials:

5-(4-chloro-phenyl)-2-ethynyl-pyridine

methyl 5-iodobenzo[b]thiophene-2-carboxylate

Downstream raw materials:

5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-benzo[b]thiophene-2-carboxylic acid