2,2-Dimethyl-1-(4-methylphenyl)cyclopropan-1-amine

Base Information

Chemical Name:2,2-Dimethyl-1-(4-methylphenyl)cyclopropan-1-amine
CAS No.:109296-41-5
Molecular Formula:C₁₂H₁₇N
Molecular Weight:175.274
Hs Code.:
DSSTox Substance ID:DTXSID001245166

Synonyms:109296-41-5;2,2-dimethyl-1-(4-methylphenyl)cyclopropan-1-amine;DTXSID001245166;2,2-Dimethyl-1-(4-methylphenyl)cyclopropanamine;EN300-1827009

Suppliers and Price of 2,2-Dimethyl-1-(4-methylphenyl)cyclopropan-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-Dimethyl-1-(4-methylphenyl)cyclopropan-1-amine

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:175.136099547
Heavy Atom Count:13
Complexity:201

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2(CC2(C)C)N

Technology Process of 2,2-Dimethyl-1-(4-methylphenyl)cyclopropan-1-amine

There total 7 articles about 2,2-Dimethyl-1-(4-methylphenyl)cyclopropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109296-34-6
N-(benzylidene)-2,2-dimethyl-1-(4-methyl)phenylcyclopropylamine

: 109296-41-5
2,2-dimethyl-1-(4-methylphenyl)cyclopropylamine

Guidance literature:: With oxalic acid; Ambient temperature;
DOI:10.1016/S0040-4039(01)80573-6

Reference yield:

: 50390-51-7
4'-methylisobutyrophenone

: 109296-41-5
2,2-dimethyl-1-(4-methylphenyl)cyclopropylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 1.) TFA; 2.) aq. NaHCO₃

2: 1.) TosCl; 2.) LiCl / 1.) pyridine; 2.) DMF

3: 93 percent / titanium tetrachloride / diethyl ether

4: 97 percent / potassium t-butoxide / tetrahydrofuran / 2 h / Heating

5: 90 percent / aq. oxalic acid / Ambient temperature

With potassium tert-butylate; oxalic acid; sodium hydrogencarbonate; p-toluenesulfonyl chloride; trifluoroacetic acid; lithium chloride; titanium tetrachloride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(01)80573-6

Reference yield:

: 121108-72-3
3-Hydroxy-2,2-dimethyl-1-p-tolyl-propan-1-one

: 109296-41-5
2,2-dimethyl-1-(4-methylphenyl)cyclopropylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) TosCl; 2.) LiCl / 1.) pyridine; 2.) DMF

2: 93 percent / titanium tetrachloride / diethyl ether

3: 97 percent / potassium t-butoxide / tetrahydrofuran / 2 h / Heating

4: 90 percent / aq. oxalic acid / Ambient temperature

With potassium tert-butylate; oxalic acid; p-toluenesulfonyl chloride; lithium chloride; titanium tetrachloride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(01)80573-6