6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline

Base Information

Chemical Name:6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline
CAS No.:290304-07-3
Molecular Formula:C₁₈H₁₆ClFN₄O
Molecular Weight:358.803
Hs Code.:

Synonyms:6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline

Chemical Property:

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Technology Process of 6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline

There total 2 articles about 6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290303-52-5
4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-6-nitro-quinazoline

: 60-29-7,927820-24-4
diethyl ether

: 7439-89-6
iron

: 290304-07-3
6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline

Guidance literature:: With ammonia; In methanol; ethanol; dichloromethane; water; acetic acid;

Reference yield:

: 290304-07-3
6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline

Guidance literature:

Reference yield: 64.0%

: 3095-95-2
diethylphosphonoacetic acid

: 290304-07-3
6-amino-4-[(3-chloro-4-fluoro-phenyl)amino]-7-cyclopropylmethoxy-quinazoline

: 365532-31-6
4-[(3-Chloro-4-fluoro-phenyl)amino]-6-{[2-(diethoxyphosphoryl)-1-oxo-ethyl]amino}-7-cyclopropylmethoxy-quinazoline

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;