cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

Base Information

Chemical Name:cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate
CAS No.:870773-62-9
Molecular Formula:C₂₇H₃₈F₂N₆O₄
Molecular Weight:548.633
Hs Code.:

cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

Synonyms:cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

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Chemical Property of cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

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Technology Process of cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

There total 7 articles about cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohex-3-en-1-yl)propyl]carbamate

: 870773-62-9
cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

: 870773-63-0
trans-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760.051 Torr;
DOI:10.1016/j.bmcl.2007.08.049

Reference yield:

: 356560-80-0
6-bromo[1,2,4]triazolo[1,5-a]pyridine

: 870773-62-9
cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide) / 14 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 24 h

With hydrogen; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

: 870773-57-2
tert-butyl [(1S,2S)-3-(dimethylamino)-1-{[3,3-difluoropyrrolidin-1-yl]carbonyl}-2-(4-oxocyclohexyl)-3-oxopropyl]carbamate

: 870773-62-9
cis-tert-butyl [(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-cyclohexyl)propyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

1.2: -78 - 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 90 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide) / 14 h / 80 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

With hydrogen; potassium acetate; potassium carbonate; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide);