4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

Base Information

Chemical Name:4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate
CAS No.:870773-59-4
Molecular Formula:C₂₂H₃₂F₅N₃O₇S
Molecular Weight:577.57
Hs Code.:

4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

Synonyms:4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

Suppliers and Price of 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

There total 2 articles about 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 870773-57-2
tert-butyl [(1S,2S)-3-(dimethylamino)-1-{[3,3-difluoropyrrolidin-1-yl]carbonyl}-2-(4-oxocyclohexyl)-3-oxopropyl]carbamate

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 870773-59-4
4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

Guidance literature:: tert-butyl [(1S,2S)-3-(dimethylamino)-1-{[3,3-difluoropyrrolidin-1-yl]carbonyl}-2-(4-oxocyclohexyl)-3-oxopropyl]carbamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at -78 - 5 ℃; Further stages.;
DOI:10.1016/j.bmcl.2007.08.049

Reference yield:

: 870773-57-2
tert-butyl [(1S,2S)-3-(dimethylamino)-1-{[3,3-difluoropyrrolidin-1-yl]carbonyl}-2-(4-oxocyclohexyl)-3-oxopropyl]carbamate

: 456-64-4
phenyl trifluoromethanesulfonamide

: 870773-59-4
4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

Guidance literature:: tert-butyl [(1S,2S)-3-(dimethylamino)-1-{[3,3-difluoropyrrolidin-1-yl]carbonyl}-2-(4-oxocyclohexyl)-3-oxopropyl]carbamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

phenyl trifluoromethanesulfonamide; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 870773-59-4
4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,3-difluoropyrrolidin-1-yl)-1-[(dimethylamino)carbonyl]-3-oxopropyl}cyclohex-1-en-1-yl trifluoromethanesulfonate

: 73183-34-3
bis(pinacol)diborane

: 870773-60-7
tert-butyl tert-butyl {(1S,2S)-1-[(3,3-difluoropyrrolidin-1-yl)carbonyl]-3-(dimethylamino)-3-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl]propyl}carbamate

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 90 ℃; for 14h;