TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE

Base Information

Chemical Name:TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE
CAS No.:106928-72-7
Molecular Formula:C22H25 N3 O6
Molecular Weight:427.457
Hs Code.:
Mol file:106928-72-7.mol

Synonyms:6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)octahydro-6,10-dioxo-,1,1-dimethylethyl ester, (1S-cis)-

Suppliers and Price of TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE

Chemical Property:

PSA：104.30000
Density:1.39
LogP:1.33500

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE

There total 15 articles about TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88767-18-4
(S,S)-5-(6-(tert-butoxycarbonyl)tetrahydropyridazin-1(2H)-yl)-4-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid

: 106928-72-7
(1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate

Guidance literature:: With thionyl chloride; In dichloromethane; for 4h; Yield given; Ambient temperature;

Reference yield:

: 88767-16-2
(S)-4-Chlorocarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid benzyl ester

: 106928-72-7
(1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaHCO₃

2: 97 percent / H₂ / Pd/C / methanol

3: PCl₅ / tetrahydrofuran

4: N-ethylmorpholine / tetrahydrofuran

With N-ethylmorpholine;; phosphorus pentachloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(99)00236-X

Reference yield:

: 106860-13-3
(S)-2-[(S)-4-Benzyloxycarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester

: 106928-72-7
(1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / Pd/C / methanol

2: PCl₅ / tetrahydrofuran

3: N-ethylmorpholine / tetrahydrofuran

With N-ethylmorpholine;; phosphorus pentachloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(99)00236-X