88767-16-2

Basic information

• Product Name: 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride
• Synonyms: 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride
• CAS NO: 88767-16-2
• Molecular Formula: C₂₀H₁₆ClNO₅
• Molecular Weight: 385.8
• Mol File: 88767-16-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride(88767-16-2)
• EPA Substance Registry System: 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride(88767-16-2)

Safety Data

• Hazardous Substances Data: 88767-16-2(Hazardous Substances Data)

Usage

Physical state

White solid

Main use

Organic synthesis

Contains phthalimide group

Yes

Importance in pharmaceutical synthesis

Important intermediate for various pharmaceuticals and fine chemicals

Use as a reagent

Preparation of acylated amino acids and peptides

Role in biologically active compounds

Key building block in the production of various biologically active compounds

Importance in the pharmaceutical industry

An important chemical

Upstream product

• 22509-74-6 N-ethoxycarbonylphthalimide 
• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 88784-33-2 (2S)-4-benzyloxicarbonyl-2-phthalimidobutanoic acid 

Downstream Products

• 88824-62-8 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88767-97-9 (1S,9S)-t-butyl 9-<(1R)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106927-97-3 (1S,9S)-t-butyl octahydro-10-oxo-9-phthalimido-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106860-19-9 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-10-oxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106860-20-2 9-amino-octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepine-1-(S)carboxylic acid t-butyl ester 
• 88768-40-5 cilazapril 
• 234752-71-7 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-N-methoxy-N-methyl-succinamic acid tert-butyl ester 
• 192755-43-4 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid tert-butyl ester 
• 192753-53-0 9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester 
• 192753-57-4 (1S,9S)-9-Benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid 
• 106928-72-7 (1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106860-13-3 (S)-2-[(S)-4-Benzyloxycarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 

Relevant articles and documents

An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9- (benzoylamino)octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1- yl]-carbonyl]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor

The title compound 1 is a potent interleukin-1β-converting enzyme (ICE) inhibitor. Recently, an efficient chiral synthesis of compound 1 has been accomplished in our labs. The overall yield of this 18-step stereoselective synthesis was 9.8%.