(S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid

Base Information

Chemical Name:(S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid
CAS No.:1372175-52-4
Molecular Formula:C₂₃H₂₀ClF₂NO₄S
Molecular Weight:479.932
Hs Code.:

Synonyms:(S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid

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Chemical Property of (S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid

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Technology Process of (S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid

There total 4 articles about (S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1372175-49-9
(S)-methyl 4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoate

: 1372175-52-4
(S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid

Guidance literature:: (S)-methyl 4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoate; With lithium hydroxide monohydrate; water; at 50 ℃; for 16h;

With hydrogenchloride; In water; pH=2; Acidic conditions;

Reference yield:

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1372175-52-4
(S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 6 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: water; lithium hydroxide monohydrate / 16 h / 50 °C

3.2: pH 2 / Acidic conditions

With lithium hydroxide monohydrate; water; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 3789-59-1
(R)-1-phenylpropylamine

: 1372175-52-4
(S)-4-((4-chloro-N-(1-phenylpropyl)phenylsulfonamido)methyl)-2,3-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 6 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: water; lithium hydroxide monohydrate / 16 h / 50 °C

3.2: pH 2 / Acidic conditions

With lithium hydroxide monohydrate; water; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;