tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

Base Information

Chemical Name:tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate
CAS No.:174258-53-8
Molecular Formula:C₃₂H₃₇F₃N₂O₇
Molecular Weight:618.65
Hs Code.:

Synonyms:tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

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Chemical Property of tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

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Technology Process of tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

There total 6 articles about tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 85006-25-3
N,N-di(tert-butoxycarbonyl)hydroxylamine

: 174258-52-7
(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-buten-1-ol

: 174258-53-8
tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 174258-53-8
tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: 81 percent / toluene; tetrahydrofuran / 48 h

5.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: 97 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; diethyl ether; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Condensation;
DOI:10.1021/jm990476x

Reference yield:

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 174258-53-8
tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: 81 percent / toluene; tetrahydrofuran / 48 h

3.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

4.1: 97 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction / 4.1: Condensation;
DOI:10.1021/jm990476x