hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid

Base Information

Chemical Name:hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid
CAS No.:174258-54-9
Molecular Formula:C₂₂H₂₁F₃N₂O₃
Molecular Weight:418.416
Hs Code.:

Synonyms:hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid

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Chemical Property of hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid

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Technology Process of hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid

There total 8 articles about hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 174258-53-8
tert-butyl (tert-butoxycarbonyl)oxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamate

: 174258-54-9
hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 8h;
DOI:10.1021/jm990476x

Reference yield: 88.0%

: 174258-54-9
hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid

Guidance literature:

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 174258-54-9
hydroxy{(E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenyl}carbamic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: 81 percent / toluene; tetrahydrofuran / 48 h

5.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: 97 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

7.1: 89 percent / TFA / CH₂Cl₂ / 8 h

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Condensation / 7.1: acidolysis;
DOI:10.1021/jm990476x