4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid

Base Information

• Chemical Name: 4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid
• CAS No.: 1352874-51-1
• Molecular Formula: C₂HF₃O₂*C₂₇H₂₃ClN₄
• Molecular Weight: 552.983
• Mol file: 1352874-51-1.mol

Synonyms:4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid

Chemical Property of 4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid

There total 6 articles about 4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

5-methyl-2-(4,4,5,5-tetramethyl)(1,3,2-dioxaborolan-2-yl)phenylamine (863578-36-3) + 1-(4-bromo-phenyl)-3-(2-chloro-benzyl)-1,3-dihydro-benzoimidazol-2-ylideneamine (1352874-26-0) → 4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid (1352874-51-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 150 ℃; for 0.283333h; Microwave radiation;

Reference yield:

4-bromo-aniline (106-40-1) → 4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid (1352874-51-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave radiation

With tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; acetonitrile;

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid (1352874-51-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave radiation

With tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; acetonitrile;

upstream raw materials:

4-bromo-aniline

ortho-nitrofluorobenzene

4-bromo-N-(2-nitrophenyl)benzenamine

N¹-(4-bromophenyl)benzene -1,2 -diamine

Downstream raw materials:

N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

Refernces