N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

Base Information

Chemical Name:N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid
CAS No.:1352872-84-4
Molecular Formula:C₂HF₃O₂*C₂₉H₂₅ClN₄O
Molecular Weight:595.021
Hs Code.:

Synonyms:N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

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Chemical Property of N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

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Technology Process of N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

There total 7 articles about N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1352874-51-1
4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-ylamine trifluoroacetic acid

: 75-36-5
acetyl chloride

: 1352872-84-4
N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1352872-84-4
N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave radiation

6.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1352872-84-4
N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-4-methyl-biphenyl-2-yl}-acetamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave radiation

6.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;