N,N-DIETHYL-3-METHYLCYCLOHEXANAMINE HYDROCHLORIDE

Base Information

• Chemical Name: N,N-DIETHYL-3-METHYLCYCLOHEXANAMINE HYDROCHLORIDE
• CAS No.: 106737-80-8
• Molecular Formula: C₁₁H₂₃N
• Molecular Weight: 169.31
• Mol file: 106737-80-8.mol

Synonyms:Cyclohexylamine,N,N-diethyl-3-methyl- (6CI); N,N-Diethyl-3-methylcyclohexylamine

Chemical Property of N,N-DIETHYL-3-METHYLCYCLOHEXANAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 3.24000
• LogP: 3.70890

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIETHYL-3-METHYLCYCLOHEXANAMINE HYDROCHLORIDE

There total 9 articles about N,N-DIETHYL-3-METHYLCYCLOHEXANAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

ethanol (64-17-5) + m-methylcyclohexanol (591-23-1) + acetonitrile (75-05-8,26809-02-9) + 3-Methylcyclohexanone (591-24-2,625-96-7) → trans-N,N-diethyl-3-methylcyclohexylamine (106737-80-8) + cis-N,N-diethyl-3-methylcyclohexylamine (106737-80-8)

Guidance literature:

aluminum oxide; lithium hydroxide; nickel; at 220 - 250 ℃; under 7600 Torr;

Reference yield: 39.0%

ethanol (64-17-5) + m-methylcyclohexanol (591-23-1) + acetonitrile (75-05-8,26809-02-9) + 3-Methylcyclohexanone (591-24-2,625-96-7) → trans-N,N-diethyl-3-methylcyclohexylamine (106737-80-8) + cis-N,N-diethyl-3-methylcyclohexylamine (106737-80-8)

Guidance literature:

aluminum oxide; lithium hydroxide; nickel; at 220 - 250 ℃; under 7600 Torr;

Reference yield:

(3R)-3-methylcyclohexanone (13368-65-5) + diethylamine (109-89-7) → N,N-diethyl-3-methylcyclohexylamine (106737-80-8)

Guidance literature:

With imine reductase from Streptomyces ipomoeae; NADPH; In water; at 30 ℃; for 0.166667h; pH=9.5; Catalytic behavior; Enzymatic reaction;

DOI:10.1002/cbic.201700257

upstream raw materials:

ethanol

m-methylcyclohexanol

acetonitrile

(3R)-3-methylcyclohexanone

Refernces

• 1、 Kozlov,Basalaeva. "Synthesis of N,N-dialkylcyclohexyl(methylcyclohexyl)amines". . p. 632 - 636. Retrieved 2007/10/03.