2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile

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Chemical Name:2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile
CAS No.:176982-87-9
Molecular Formula:C₃₃H₃₅N₃O₇
Molecular Weight:585.657
Hs Code.:

Synonyms:2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile

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Chemical Property of 2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile

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Technology Process of 2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile

There total 3 articles about 2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3598-60-5
4-phthalimidobutanal

: (4-Benzyloxy-3,5-dimethoxy-phenyl)-morpholin-4-yl-acetonitrile

: 176982-87-9
2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1016/0040-4039(96)00499-6

Reference yield:

: 85-44-9
phthalic anhydride

: 176982-87-9
2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / toluene / Heating

2: 89 percent / Swern oxidation

3: 82 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene;
DOI:10.1016/0040-4039(96)00499-6

Reference yield:

: 24697-70-9
N-(4-hydroxybutyl)phthalimide

: 176982-87-9
2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Swern oxidation

2: 82 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/0040-4039(96)00499-6