methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

Base Information

Chemical Name:methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate
CAS No.:1403326-88-4
Molecular Formula:C₂₄H₂₇ClO₃
Molecular Weight:398.93
Hs Code.:

Synonyms:methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

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Chemical Property of methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

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Technology Process of methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

There total 15 articles about methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6683-48-3
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

: 2-chloro-4-chlorocarbonyl-benzoic acid methyl ester

: 1403326-88-4
methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

Guidance literature:: 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene; 2-chloro-4-chlorocarbonyl-benzoic acid methyl ester; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 0.333333h; Reflux;

With hydrogenchloride; water; In dichloromethane;
DOI:10.1002/cmdc.201200319

Reference yield:

: 6683-48-3
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

: 299173-15-2
4-carbomethoxy-3-iodobenzoyl chloride

: 1403326-88-4
methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

: 1403326-90-8
methyl 2-iodo-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

Guidance literature:: 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene; 4-carbomethoxy-3-iodobenzoyl chloride; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 0.333333h; Reflux;

With hydrogenchloride; water; In dichloromethane; Overall yield = 89 %; Overall yield = 2.91 g;
DOI:10.1002/cmdc.201200319

Reference yield:

: 5162-82-3
3-chloro-4-methylbenzoic acid

: 1403326-88-4
methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dibenzoyl peroxide / tetrachloromethane / 36 h / Reflux

2.1: silver nitrate; water / ethanol / 0.75 h / 50 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h

3.2: 5 h / 20 °C

4.1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 1 h / 20 °C

5.1: thionyl chloride / 1 h / 84 °C

6.1: triethylamine / 1.17 h / 20 °C

7.1: hydrogen; 10% Pd/C / ethyl acetate; ethanol / 20 °C

8.1: thionyl chloride / 1 h / 85 °C

9.1: aluminum (III) chloride / dichloromethane / 0.33 h / 20 °C / Reflux

With aluminum (III) chloride; sodium chlorite; thionyl chloride; 10% Pd/C; aminosulfonic acid; water; hydrogen; sodium hydride; silver nitrate; triethylamine; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1002/cmdc.201200319