Technology Process of methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate
There total 15 articles about methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene; 2-chloro-4-chlorocarbonyl-benzoic acid methyl ester;
With
aluminum (III) chloride;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
Reflux;
With
hydrogenchloride; water;
In
dichloromethane;
DOI:10.1002/cmdc.201200319
- Guidance literature:
-
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene; 4-carbomethoxy-3-iodobenzoyl chloride;
With
aluminum (III) chloride;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
Reflux;
With
hydrogenchloride; water;
In
dichloromethane;
Overall yield = 89 %; Overall yield = 2.91 g;
DOI:10.1002/cmdc.201200319
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dibenzoyl peroxide / tetrachloromethane / 36 h / Reflux
2.1: silver nitrate; water / ethanol / 0.75 h / 50 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h
3.2: 5 h / 20 °C
4.1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 1 h / 20 °C
5.1: thionyl chloride / 1 h / 84 °C
6.1: triethylamine / 1.17 h / 20 °C
7.1: hydrogen; 10% Pd/C / ethyl acetate; ethanol / 20 °C
8.1: thionyl chloride / 1 h / 85 °C
9.1: aluminum (III) chloride / dichloromethane / 0.33 h / 20 °C / Reflux
With
aluminum (III) chloride; sodium chlorite; thionyl chloride; 10% Pd/C; aminosulfonic acid; water; hydrogen; sodium hydride; silver nitrate; triethylamine; dibenzoyl peroxide;
In
tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1002/cmdc.201200319
