8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester

Base Information

Chemical Name:8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester
CAS No.:157993-51-6
Molecular Formula:C₂₁H₂₇NO₅Si
Molecular Weight:401.535
Hs Code.:

Synonyms:8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester

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Chemical Property of 8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester

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Technology Process of 8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester

There total 4 articles about 8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 922-67-8
propynoic acid methyl ester

: 157993-50-5
N-phenoxycarbonyl-3-(1-trimethylsilyloxyvinyl)-1,2,5,6-tetrahydropyridine

: 157993-51-6
8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester

Guidance literature:: In nitrobenzene; for 2h; Heating;

Reference yield:

: 55806-53-6
Arecolone

: 157993-51-6
8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / K₂CO₃ / benzene / 2.5 h / Heating

2: 1.) LDA / 1. THF, -78 deg C, 2 h, 2.) THF, -78 deg C, 0.5 h

3: 68 percent / nitrobenzene / 2 h / Heating

With potassium carbonate; lithium diisopropyl amide; In nitrobenzene; benzene;

Reference yield:

: 1885-14-9
phenyl chloroformate

: 157993-51-6
8-Trimethylsilanyloxy-3,4,4a,7-tetrahydro-1H-isoquinoline-2,5-dicarboxylic acid 5-methyl ester 2-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / K₂CO₃ / benzene / 2.5 h / Heating

2: 1.) LDA / 1. THF, -78 deg C, 2 h, 2.) THF, -78 deg C, 0.5 h

3: 68 percent / nitrobenzene / 2 h / Heating

With potassium carbonate; lithium diisopropyl amide; In nitrobenzene; benzene;