2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

Base Information

Chemical Name:2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine
CAS No.:1088994-37-9
Molecular Formula:C₂₁H₂₂BrFN₂O₂
Molecular Weight:433.32
Hs Code.:

Synonyms:2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

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Chemical Property of 2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

Chemical Property:

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Technology Process of 2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

There total 13 articles about 2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: potassium ethyltrifluoroboranuide

: 1088994-34-6
2-(((3R,6R)-1-(2-bromo-5-iodo-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

: 1088994-37-9
2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 20 - 85 ℃; for 77h;

Reference yield:

: 25252-00-0
2-bromo-5-iodobenzoic acid

: 1088994-37-9
2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / N,N-dimethyl-formamide / 18 h / 22 °C

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 77 h / 20 - 85 °C

With potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide;

Reference yield:

: 278789-37-0
(6-methyl-piperidin-3-yl)methanol

: 1088994-37-9
2-(((3R,6R)-1-(2-bromo-5-vinyl-benzoyl)-6-methyl-piperidin-3-yl)methoxy)-5-fluoro-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 22 °C

2: ethanol; hexane / Resolution of racemate

3: PS-triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane

4: hydrogen / 10 % Pd(OH)2/C / ethanol / 0.67 h / 22 °C / 760.05 Torr

5: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / N,N-dimethyl-formamide / 18 h / 22 °C

6: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 77 h / 20 - 85 °C

With PS-triphenylphosphine; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 10 % Pd(OH)2/C; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;