4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile

Base Information

Chemical Name:4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile
CAS No.:1609078-42-3
Molecular Formula:C₂₉H₃₂N₄O
Molecular Weight:452.599
Hs Code.:

Synonyms:4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile

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Technology Process of 4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile

There total 7 articles about 4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

: 10136-57-9
5-(chloromethyl)quinolin-8-ol

: 1609078-49-0
4-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)butanenitrile

: 1609078-42-3
4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2014.04.078

Reference yield: 65.4%

: 1609078-49-0
4-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)butanenitrile

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 1609078-42-3
4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 151097-69-7
(2E)-3-(1-benzylpiperidin-4-yl)prop-2-enenitrile

: 1609078-42-3
4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: magnesium; iodine / methanol / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C

3: 0.17 h / 125 °C / Microwave irradiation

4: triethylamine / dichloromethane / 0 - 20 °C

With iodine; diisobutylaluminium hydride; magnesium; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 3: |Strecker Aminoacid Synthesis;
DOI:10.1016/j.ejmech.2014.04.078