(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

Base Information

Chemical Name:(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride
CAS No.:1351940-22-1
Molecular Formula:C₃₂H₃₁ClN₆O₄*ClH
Molecular Weight:635.55
Hs Code.:

(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

Synonyms:(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

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Chemical Property of (E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

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Technology Process of (E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

There total 15 articles about (E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351940-21-0
(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

: 1351940-22-1
(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; for 0.166667h;

Reference yield:

: 1351942-49-8
4-chloro-6-nitro-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351940-22-1
(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

2.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice

4.1: sodium iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

4.2: 20 °C

5.1: hydrogenchloride / methanol; diethyl ether / 0.17 h

With hydrogenchloride; tin(II) chloride dihdyrate; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1351942-44-3
(E/Z)-ethyl 2-cyano-3-(4-nitro-3-(tetrahydrofuran-3-yl-oxy)-phenylamino)-acrylate

: 1351940-22-1
(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: biphenyl; diphenylether / 2 h / 256 °C / Inert atmosphere

2.1: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

3.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

4.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice

6.1: sodium iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

6.2: 20 °C

7.1: hydrogenchloride / methanol; diethyl ether / 0.17 h

With hydrogenchloride; tin(II) chloride dihdyrate; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; trichlorophosphate; In tetrahydrofuran; methanol; diphenylether; biphenyl; diethyl ether; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;