(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

Base Information

Chemical Name:(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide
CAS No.:1351940-21-0
Molecular Formula:C₃₂H₃₁ClN₆O₄
Molecular Weight:599.089
Hs Code.:

Synonyms:(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

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Chemical Property of (E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

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Technology Process of (E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

There total 14 articles about (E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1351940-20-9
(E)-4-bromo-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-but-2-enamide

: 506-59-2
N,N-dimethylammonium chloride

: 1351940-21-0
(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

Guidance literature:: (E)-4-bromo-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-but-2-enamide; With sodium iodide; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere; Cooling with ice;

N,N-dimethylammonium chloride; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1351942-44-3
(E/Z)-ethyl 2-cyano-3-(4-nitro-3-(tetrahydrofuran-3-yl-oxy)-phenylamino)-acrylate

: 1351940-21-0
(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: biphenyl; diphenylether / 2 h / 256 °C / Inert atmosphere

2.1: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

3.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

4.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice

6.1: sodium iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

6.2: 20 °C

With tin(II) chloride dihdyrate; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; trichlorophosphate; In tetrahydrofuran; diphenylether; biphenyl; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1351942-49-8
4-chloro-6-nitro-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351940-21-0
(E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-4-(dimethylamino)-but-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

2.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice

4.1: sodium iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

4.2: 20 °C

With tin(II) chloride dihdyrate; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;