3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine

Base Information

Chemical Name:3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine
CAS No.:123837-02-5
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine

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Technology Process of 3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine

There total 2 articles about 3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64133-02-4
α-(tetrahydropyranyloxy)benzyl cyanide

: 123837-02-5
3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / Na, NH₂OH*HCl / methanol / 16 h

2: 1.) NaH, 4A molecular sieves / 1.) THF, 50 deg C, 0.5 h, 2.) reflux, 4 h

With 4 A molecular sieve; hydroxylamine hydrochloride; sodium; sodium hydride; In methanol;
DOI:10.1021/jm00166a008

Reference yield:

: 38206-86-9
methyl quinuclidine-3-carboxylate

: 123837-01-4
α-(tetrahydropyranyloxy)phenylacetamide oxime

: 123837-02-5
3-<3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-1,2,4-oxadiazol-5-yl>quinuclidine

Guidance literature:: With 4 A molecular sieve; sodium hydride; Yield given. Multistep reaction; 1.) THF, 50 deg C, 0.5 h, 2.) reflux, 4 h;
DOI:10.1021/jm00166a008