(E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene

Base Information

• Chemical Name: (E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene
• CAS No.: 169560-26-3
• Molecular Formula: C₁₇H₂₂O₂S
• Molecular Weight: 290.426
• Mol file: 169560-26-3.mol

Synonyms:(E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene

Chemical Property of (E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene

There total 3 articles about (E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

3-<(1S,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene (169560-25-2) → (E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene (169560-26-3)

Guidance literature:

With rhodium(III) chloride; In ethanol; for 24h; Heating;

DOI:10.1248/cpb.43.571

Reference yield:

3-<(1S,6R)-6-((S)-p-tolylsulfinyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene (140629-82-9) → (E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene (169560-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 30percent H₂O₂ / acetic acid / 12 h / Ambient temperature

2: 46 percent / RhCl₃*3H₂O / ethanol / 24 h / Heating

With rhodium(III) chloride; dihydrogen peroxide; In ethanol; acetic acid;

DOI:10.1248/cpb.43.571

Reference yield:

3-<(1S,6R)-6-(p-tolylthio)bicyclo<4.1.0>hept-1-yl>prop-1-ene (169560-24-1) → (E)-1-<(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene (169560-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 28 percent / MCPBA / CH₂Cl₂ / 0.08 h / 0 °C

2: 93 percent / 30percent H₂O₂ / acetic acid / 12 h / Ambient temperature

3: 46 percent / RhCl₃*3H₂O / ethanol / 24 h / Heating

With rhodium(III) chloride; dihydrogen peroxide; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; acetic acid;

DOI:10.1248/cpb.43.571

upstream raw materials:

3-<(1S,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene

3-<(1S,6R)-6-(p-tolylthio)bicyclo<4.1.0>hept-1-yl>prop-1-ene

3-<(1S,6R)-6-((S)-p-tolylsulfinyl)bicyclo<4.1.0>hept-1-yl>prop-1-ene

Downstream raw materials:

(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>hept-1-ylmethanol

(1R,6R)-6-(p-tolylsulfonyl)bicyclo<4.1.0>heptanecarbaldehyde