140629-82-9Relevant academic research and scientific papers
Asymmetric cyclopropanation by reaction of a γ-chloromethylated chiral vinylic sulfoxide with allylmagnesium bromide
Takemoto,Ohra,Sugiyama,Imanishi,Iwata
, p. 571 - 577 (2007/10/02)
An optically active vinylic sulfoxide bearing a leaving group at the γ-position was stereoselectively transformed into a chiral cyclopropane by means of a Michael addition with an allylmagnesinm bromide. The Michael induced ring-closure reaction requires both allylmagnesium bromide as a nucleophile and chloride as a leaving group for high diastereoselectivity. The absolute stereochemistry of the cycloadduct was confirmed by X-ray analysis.
Novel Asymmetric Cyclopropanation Utilizing Sulfinyl Chirality: Application to Construction of a Spirodecane System
Imanishi, Takeshi,Ohra, Taiichi,Sugiyama, Kenji,Ueda, Yoko,Takemoto, Yoshiji,Iwata, Chuzo
, p. 269 - 270 (2007/10/02)
An optically active vinylic sulfoxide is stereoselectively transformed into a chiral cyclopropane by means of a Michael addition reaction with an allyl Grignard reagent, and using this novel cyclopropanation, asymmetric construction of a spirodecane
