N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Name:N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
CAS No.:859838-22-5
Molecular Formula:C₃₂H₅₁N₃O₈Si₂
Molecular Weight:661.943
Hs Code.:

<i>N</i>-{1-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Synonyms:N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Property of N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Technology Process of N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 4 articles about N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859838-21-4
N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

: 107-31-3
Methyl formate

: 859838-22-5
N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 4h;

Methyl formate; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1016/j.tetlet.2005.04.083

Reference yield:

: 859838-24-7
4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

: 859838-22-5
N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / dimethylformamide / 0.25 h / 160 °C / microwave irradiation

2.1: LDA / tetrahydrofuran / 4 h / -78 °C

2.2: tetrahydrofuran / 3 h / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.04.083

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 859838-22-5
N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-6-formyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / imidazole / dimethylformamide / 4 h / 20 °C

2.1: 99 percent / dimethylformamide / 0.25 h / 160 °C / microwave irradiation

3.1: LDA / tetrahydrofuran / 4 h / -78 °C

3.2: tetrahydrofuran / 3 h / -78 °C

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.04.083