8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

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Chemical Name:8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate
CAS No.:1259039-34-3
Molecular Formula:C₃₆H₅₅N₉O₈S₂
Molecular Weight:806.02
Hs Code.:

8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Synonyms:8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

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Chemical Property of 8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

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Technology Process of 8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

There total 4 articles about 8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259039-29-6
8-(tert-butyl) 3-ethyl (R)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

: 1259039-33-2
2,2'-[{[4-(chloromethyl)benzyl]imino}bis(methylene)]bis(N,N-dimethyl-1H-imidazole-1-sulfonamide)

: 1259039-34-3
8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃; for 15h; Inert atmosphere;

Reference yield:

: 937074-59-4
2,2'-[{[4-(diethoxymethyl)benzyl]imino}bis(methylene)]bis(N,N-dimethyl-1H-imidazole-1-sulfonamide)

: 1259039-34-3
8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / ethyl acetate / 0.05 h / 20 °C

2: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 1 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 15 h / 50 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; water; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; ethyl acetate; acetonitrile;

Reference yield:

: 1259039-31-0
2,2'-[[(4-formylbenzyl)imino]bis(methylene)]bis(N,N-dimethyl-1H-imidazole-1-sulfonamide)

: 1259039-34-3
8-tert-butyl 3-ethyl (3R)-2-(4-{[bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)amino]methyl}benzyl)-2,8-diazaspiro[4.5]decane-3,8-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 1 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 15 h / 50 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; acetonitrile;