1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil

Base Information

• Chemical Name: 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil
• CAS No.: 55264-13-6
• Molecular Formula: C₂₁H₃₈N₂O₅Si₂
• Molecular Weight: 454.714

Synonyms:1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil

Chemical Property of 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil

There total 1 articles about 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

benzaldehyde (100-52-7) + 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-deoxy-2-bromo-D-erythro-pento-1-enofuranosyl]uracil (162143-59-1) → 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-deoxy-2-C-(1-phenylhydroxymethyl)erythropento-1-enofuranosyl]uracil + 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-deoxy-2-C-(1-phenylhydroxymethyl)erythropento-1-enofuranosyl]uracil + 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil (55264-13-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Optical yield = 75 percent de; Inert atmosphere;

DOI:10.1080/15257770.2019.1641724

Reference yield: 21.0%

thiophenol (108-98-5) + 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil (55264-13-6) → 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-furan-2-yl]-1H-pyrimidine-2,4-dione (135824-42-9) + 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-1'-C-(phenylthio)uridine + 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenylsulfanyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:

In dichloromethane; at 20 ℃; for 120h;

DOI:10.1021/jo0201934

Reference yield: 3.0%

Phenylselenyl chloride (5707-04-0) + 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil (55264-13-6) → (4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenylselanyl-dihydro-furan-2-one + 1-[(4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenylselanyl-4,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:

With silver(I) acetate; In toluene; Ambient temperature;

DOI:10.1016/S0040-4039(00)91829-X

upstream raw materials:

benzaldehyde

1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-deoxy-2-bromo-D-erythro-pento-1-enofuranosyl]uracil

Downstream raw materials:

(5S)-5-(tert-butyldimethylsilanyloxymethyl)-5H-furan-2-one

1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-furan-2-yl]-1H-pyrimidine-2,4-dione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 55264-13-6 1-<3,5-Bis-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pent-1-enofuranosyl>uracil

Send

Send

Metric Ton KG G Pound L ML

Send

Send