ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate

Base Information

• Chemical Name: ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate
• CAS No.: 40019-25-8
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.238
• Hs Code.: 2934999090
• Mol file: 40019-25-8.mol

Synonyms:ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate

Chemical Property of ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-(4-methoxyphenyl)-[1,2,4]oxadiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

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Technology Process of ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate

There total 6 articles about ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methoxybenzamidoxime (5373-87-5) + Ethyl oxalyl chloride (4755-77-5) → ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate (40019-25-8)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 80 ℃; for 3.5h;

DOI:10.1134/S1070428014110232

Reference yield: 82.0%

chloroacetic acid ethyl ester (105-39-5) + para-methoxy-benzamidoxime (192332-47-1,5373-87-5,1079393-88-6) → ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate (40019-25-8)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 5.5h; Reflux;

DOI:10.1016/j.bmc.2018.06.028

Reference yield: 74.0%

(Z)-N'-hydroxy-4-methoxybenzenecarboximidamide (5373-87-5) + Ethyl oxalyl chloride (4755-77-5) → ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate (40019-25-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 5 ℃; for 2h; Reflux;

DOI:10.1016/j.jorganchem.2017.04.014

upstream raw materials:

4-methoxybenzamidoxime

Ethyl oxalyl chloride

4-methoxybenzonitrile

(Z)-N'-hydroxy-4-methoxybenzenecarboximidamide

Downstream raw materials:

3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carbohydrazide

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