5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol

Base Information

Chemical Name:5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol
CAS No.:33184-37-1
Molecular Formula:C₁₇H₁₆N₂O
Molecular Weight:264.327
Hs Code.:

Synonyms:5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol

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Technology Process of 5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol

There total 3 articles about 5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 99-75-2
4-methyl-benzoic acid methyl ester

: 936-49-2
2-phenyl-2-imidazoline

: 33184-37-1
5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol

Guidance literature:: 2-phenyl-2-imidazoline; With n-butyllithium; In tetrahydrofuran; hexane; at 50 ℃; for 3h;

4-methyl-benzoic acid methyl ester; In tetrahydrofuran; hexane; at 50 ℃; for 6h; Further stages.;
DOI:10.1021/jm010302r

Reference yield:

: 670-96-2
2-Phenylimidazole

: 94-08-6
4-methylbenzoic acid ethyl ester

: 27035-87-6
C₁₇H₁₆N₂O

: 33184-37-1
5-p-tolyl-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol

Guidance literature:: 2-Phenylimidazole; With n-butyllithium; In tetrahydrofuran; hexane; at 50 ℃; for 3.5h; Inert atmosphere;

4-methylbenzoic acid ethyl ester; In tetrahydrofuran; hexane; at 50 ℃; for 6h; Overall yield = 48 %; Overall yield = 886 mg; Inert atmosphere;
DOI:10.1124/mol.113.088922