(S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:(S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile
CAS No.:1371608-88-6
Molecular Formula:C₁₂H₉F₃N₂O₃
Molecular Weight:286.21
Hs Code.:

Synonyms:(S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile

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Chemical Property of (S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile

Chemical Property:

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Technology Process of (S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile

There total 4 articles about (S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1371608-87-5
(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2-oxooxazolidine-4-carboxylate

: 1371608-88-6
(S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1371608-88-6
(S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 4 h / 80 °C

2.1: potassium hydroxide / diethyl ether

2.2: 1 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

4.1: ethanol; sodium tetrahydroborate / 1 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In diethyl ether; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1371608-84-2
(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

: 1371608-88-6
(S)-4-(4-(hydroxymethyl)-2-oxooxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / diethyl ether

1.2: 1 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

3.1: ethanol; sodium tetrahydroborate / 1 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In diethyl ether; dichloromethane;