(R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

Base Information

Chemical Name:(R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate
CAS No.:1371608-85-3
Molecular Formula:C₁₂H₁₁F₃N₂O₃
Molecular Weight:288.226
Hs Code.:

Synonyms:(R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

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Chemical Property of (R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

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Technology Process of (R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

There total 2 articles about (R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 684-93-5
1-methyl-1-nitrosourea

: 1371608-84-2
(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

: 1371608-85-3
(R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

Guidance literature:: 1-methyl-1-nitrosourea; With potassium hydroxide; In diethyl ether;

(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1371608-85-3
(R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 4 h / 80 °C

2.1: potassium hydroxide / diethyl ether

2.2: 1 h / 0 °C

With potassium carbonate; potassium hydroxide; In diethyl ether; dimethyl sulfoxide;

Reference yield:

: 1371608-85-3
(R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

: C₁₆H₁₆F₆N₂O₃Si

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

2: ethanol; sodium tetrahydroborate / 1 h / 0 - 20 °C / Inert atmosphere

3: Dess-Martin periodane / acetonitrile / 10 h / 0 °C / Inert atmosphere

4: cesium fluoride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; cesium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;