(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

Base Information

Chemical Name:(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid
CAS No.:1371608-84-2
Molecular Formula:C₁₁H₉F₃N₂O₃
Molecular Weight:274.199
Hs Code.:

Synonyms:(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

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Chemical Property of (R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

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Technology Process of (R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

There total 1 articles about (R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 312-84-5,83245-15-2
D-Serine

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1371608-84-2
(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

Guidance literature:: D-Serine; 4-fluoro-2-(trifluoromethyl)benzonitrile; With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 4h;

With citric acid; In water;

Reference yield: 90.0%

: 684-93-5
1-methyl-1-nitrosourea

: 1371608-84-2
(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

: 1371608-85-3
(R)-methyl-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoate

Guidance literature:: 1-methyl-1-nitrosourea; With potassium hydroxide; In diethyl ether;

(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

Reference yield:

: 1371608-84-2
(R)-2-(4-cyano-3-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

: 1371608-87-5
(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2-oxooxazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / diethyl ether

1.2: 1 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; potassium hydroxide; In diethyl ether; dichloromethane;