N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea

Base Information

Chemical Name:N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea
CAS No.:1246391-76-3
Molecular Formula:C₂₁H₁₆ClF₃N₄OS₂
Molecular Weight:496.964
Hs Code.:

Synonyms:N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea

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Technology Process of N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea

There total 7 articles about N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 284462-87-9
4-[(4-aminophenylthio)(2-pyridyl)]-N-methylcarboxamide

: 23163-86-2
1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene

: 1246391-76-3
N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 22h;
DOI:10.1007/s00044-012-0400-8

Reference yield:

: 220000-87-3
4-chloro-N-methylpicolinamide

: 1246391-76-3
N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

1.2: 80 °C

2.1: dichloromethane / 20 °C / Inert atmosphere

With potassium tert-butylate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 98-98-6
2-Picolinic acid

: 1246391-76-3
N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 40 - 72 °C

2.1: water; toluene / -5 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.2: 80 °C

4.1: dichloromethane / 20 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;