2-benzyloxy-3,5-di-tert-butylbenzoyl chloride

Base Information

• Chemical Name: 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride
• CAS No.: 175650-10-9
• Molecular Formula: C₂₂H₂₇ClO₂
• Molecular Weight: 358.908
• Mol file: 175650-10-9.mol

Synonyms:2-benzyloxy-3,5-di-tert-butylbenzoyl chloride

Chemical Property of 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride

There total 5 articles about 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-benzyloxy-3,5-di-tert-butylbenzoic acid (175650-09-6) → 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride (175650-10-9)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 40 - 45 ℃;

DOI:10.1002/cber.19961290113

Reference yield:

methyl 3,5-di-tert-butyl-2-benzyloxybenzoate (853268-35-6) → 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride (175650-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / KOH / H₂O; methanol / 4 h / Heating

2: oxalyl chloride / CH₂Cl₂; dimethylformamide / 4 h / 20 °C

With potassium hydroxide; oxalyl dichloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.02.064

Reference yield:

methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate (15018-03-8) → 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride (175650-10-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

2: 75 percent / KOH / H₂O; methanol / 4 h / Heating

3: oxalyl chloride / CH₂Cl₂; dimethylformamide / 4 h / 20 °C

With potassium hydroxide; oxalyl dichloride; potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.02.064

upstream raw materials:

2-benzyloxy-3,5-di-tert-butylbenzoic acid

methyl 3,5-di-tert-butyl-2-benzyloxybenzoate

methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

benzyl bromide

Downstream raw materials:

2,6-bis-(3,5-di-tert-butyl-2-benzyloxybenzamido)pyridine

1,2-bis-(3,5-di-tert-butyl-2-benzyloxybenzamido)benzene

1,8-bis-(3,5-di-tert-butyl-2-benzyloxybenzamido)naphthalene

1,2-bis-(3,5-di-tert-butyl-2-hydroxybenzamido)benzene