(2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

Base Information

Chemical Name:(2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile
CAS No.:1402829-74-6
Molecular Formula:C₃₀H₃₈N₂OSi
Molecular Weight:470.73
Hs Code.:

Synonyms:(2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

Chemical Property:

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Technology Process of (2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

There total 6 articles about (2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 118970-37-9
(2S,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanenitrile

: 1402829-74-6
(2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/cmdc.201200271

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1402829-74-6
(2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; potassium carbonate / water / 3 h / Reflux

2.1: lithium aluminium tetrahydride / diethyl ether / 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 0 °C

3.2: 1 h

4.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / -20 °C

5.1: 1H-imidazole / dichloromethane / 0 - 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; potassium carbonate; dimethyl sulfoxide; sodium hydroxide; In diethyl ether; dichloromethane; water; 3.1: |Swern Oxidation;
DOI:10.1002/cmdc.201200271

Reference yield:

: 123054-12-6,123808-74-2,136370-73-5,111060-64-1
(2S)-N,N-dibenzylphenylalaninal

: 1402829-74-6
(2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 2 h / -20 °C

2: 1H-imidazole / dichloromethane / 0 - 20 °C

With 1H-imidazole; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1002/cmdc.201200271