118970-37-9

Upstream product

• 123054-12-6 (2S)-N,N-dibenzylphenylalaninal 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 7732-18-5 water 
• 95437-43-7 (S)-2-(N,N-dibenzylamino)-3-phenylpropanoic acid 
• 111060-52-7 (S)-2-(dibenzylamino)-3-phenylpropan-1-ol 
• 100-39-0 benzyl bromide 
• 5804-85-3 diethylaluminium cyanide 

Downstream Products

• 153291-28-2 (2S,3S)-3-(N,N-dibenzylamino)-2-hydroxy-4-phenylbutyric acid 
• 62023-62-5 allophenylnorstatine 
• 111060-52-7 (S)-2-(dibenzylamino)-3-phenylpropan-1-ol 
• 170359-24-7 (2R,3S)-1-amino-3-(dibenzylamino)-4-phenylbutan-2-ol 
• 1402829-75-7 C₃₄H₅₀N₂OSi 
• 169331-42-4 βS--αR-<<(2-methylpropyl)amino>methyl>-benzenepropanol 
• 799241-79-5 N-((2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide 
• 159005-71-7 N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide 
• 1402829-74-6 (2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile 

Relevant academic research and scientific papers

An Efficient Synthesis of a Hydroxyethylamine (HEA) Isostere and Its α-Aminophosphonate and Phosphoramidate Derivatives as Potential Anti-HIV Agents

HIV protease is a promising drug target for AIDS therapy, and several potent HIV-1 protease inhibitors have been reported to date. Although existing inhibitors exhibit high selectivity, they have also been associated with severe side effects and the possi

Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: A route to enantiopure β-amino-α-hydroxy acids

Chiral α-dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-β-dibenzylamino-α-hydroxycyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure β-amino-α-hydroxy acids.

Practical synthesis of (2S,3S)-3-amino-2 hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors

Synthesis of (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid was achieved by the highly diastereoselective cyanohydrin formation of (S)-2-N,N- dibenzylamino-3-phenylpropanal with acetone cyanohydrin in the presence of trimethyl-aluminum as a key step.

Process for the preparation of 3-amino-2-hydroxy-4-phenylbutyronitrile derivatives

3-Amino-2-hydroxy-4-phenylbutyronitrile derivatives represented by the formula (3) may be prepared by reacting an aminoaldehyde derivative represented by the formula (1) with a cyanohydrin derivative represented by the formula (2) in the presence of a met

Optically active α-amino aldehydes, process for the preparation thereof, and the use thereof for the stereoselective preparation of optically active β-amino alcohols

The invention relates to new optically active α-amino aldehydes of the formulae STR1 in which R1 represents an optionally substituted alkyl, alkenyl, aralkyl or aryl radical, and R2 and R3, independently of one another, denote an optionally substituted alkyl, alkenyl, cycloalkyl or aralkyl group, together form an optionally substituted phenylene-(1,2)-bis-methylene radical, or R2 is an optionally substituted, alkyl, cycloalkyl or aralkyl radical, and R3 forms together with R1 a 1,3-propylene radical. a process for the preparation thereof, and the use thereof for the stereoselective preparation of optically active β-amino alcohols.

STEREOSELECTIVE CYANOHYDRIN-FORMING REACTIONS OF CHIRAL α-AMINO ALDEHYDES

The Lewis acid mediated cyanohydrin-forming addition of Me3SiCN to optically active α-dibenzylamino aldehydes 2 occurs stereoselectively.Chelation controlled adducts 3 result if MgBr2 or TiCl4 is used, whereas the diastereomers 4 are obtained upon employi