1-(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)ethan-1-ol

Base Information

• Chemical Name: 1-(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)ethan-1-ol
• CAS No.: 33647-67-5
• Molecular Formula: C8H14 O4
• Molecular Weight: 174.197
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID90955272
• Wikidata: Q82934792
• Mol file: 33647-67-5.mol

Synonyms:DTXSID90955272;1-(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)ethan-1-ol

Chemical Property of 1-(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)ethan-1-ol

Chemical Property:

• Vapor Pressure: 0.00171mmHg at 25°C
• Refractive Index: 1.4455 (estimate)
• Boiling Point: 64-68 °C (1 mmHg)
• Flash Point: 111.6°C
• PSA: 47.92000
• Density: 1.13g/cm³
• LogP: 0.26880
• Storage Temp.: 0-6°C
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 174.08920892
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

99% ^*data from raw suppliers

DL-1-(2,5-DIMETHOXY-2,5-DIHYDROFURAN-2-YL)ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1(C=CC(O1)OC)OC)O
• Isomeric SMILES: C[C@@H]([C@@]1(C=C[C@@H](O1)OC)OC)O

Technology Process of 1-(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)ethan-1-ol

There total 9 articles about 1-(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(2-furyl)ethanol (4208-64-4) + methanol (67-56-1) → 1-(2,5-dimethoxy-2,5-dihydrofuran-2-yl)ethanol from 2-Acetylfuran (33647-67-5,316186-17-1,236408-20-1)

Guidance literature:

With piperidine; silica gel; Electrochemical reaction;

DOI:10.1002/chem.200500340

Reference yield: 89.0%

methanol (67-56-1) + (S)-1-(2-furanyl)ethanol (4208-64-4,27948-61-4,106565-48-4,112653-32-4) → (S)-1-(2,5-dihydro-2,5-dimethoxy-2-furyl)ethanol (33647-67-5,316186-17-1,236408-20-1)

Guidance literature:

With bromine; In diethyl ether; at -40 ℃; for 0.5h;

DOI:10.1016/j.carres.2006.01.019

Reference yield:

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → (S)-1-(2,5-dihydro-2,5-dimethoxy-2-furyl)ethanol (33647-67-5,316186-17-1,236408-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Et₃N / Ru(II) complex from (1S,2S)-N-(pTs)-1,2-diPhethylenediamine / formic acid / 42 h / 20 °C

2: 89 percent / Br₂ / diethyl ether / 0.5 h / -40 °C

With bromine; triethylamine; Ru(II)-(1S,2S)-N-p-toluenesulfonyl-1,2-di-Ph-ethylenediamine; In formic acid; diethyl ether;

DOI:10.1016/j.carres.2006.01.019

upstream raw materials:

methanol

1-(3'-furyl)-ethanol

1-(2-furyl)ethanol

1-(2-furyl)-1-ethanone

Downstream raw materials:

methyl 2,3,6-trideoxy-α-DL-glycero-hex-2-enopyranosid-4-ulose

methyl 2,3,6-trideoxy-β-DL-glycero-hex-2-enopyranosid-4-ulose

1-(2-furyl)-1-ethanone

1-(2-furyl)ethanol