N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide

Base Information

• Chemical Name: N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide
• CAS No.: 1313027-77-8
• Molecular Formula: C₂₁H₂₂Cl₂N₄O₂S
• Molecular Weight: 465.403
• Mol file: 1313027-77-8.mol

Synonyms:N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide

Chemical Property of N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide

There total 3 articles about N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide (1313027-61-0) + acetic anhydride (108-24-7) → N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide (1313027-77-8)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2011.04.013

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide (1313027-77-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / water

2.1: hydrazine hydrate

3.1: ethanol

3.2: 12 h / 60 °C

4.1: Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol; water;

DOI:10.1016/j.ejmech.2011.04.013

Reference yield:

cyclohexylthiocarbamoylsulfanyl-acetic acid (112864-51-4) → N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide (1313027-77-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate

2.1: ethanol

2.2: 12 h / 60 °C

3.1: Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.ejmech.2011.04.013

upstream raw materials:

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide

acetic anhydride

cyclohexylamine

cyclohexylthiocarbamoylsulfanyl-acetic acid