1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide

Base Information

• Chemical Name: 1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide
• CAS No.: 1313027-61-0
• Molecular Formula: C₁₇H₁₈Cl₂N₄S
• Molecular Weight: 381.329
• Mol file: 1313027-61-0.mol

Synonyms:1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide

Chemical Property of 1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide

There total 3 articles about 1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-cyclohexyl-thiosemicarbazide (21198-18-5) + 2,8-dichloroquinoline-3-carbaldehyde (144918-96-7) → 1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide (1313027-61-0)

Guidance literature:

4-cyclohexyl-thiosemicarbazide; 2,8-dichloroquinoline-3-carbaldehyde; In ethanol;

With acetic acid; In ethanol; at 60 ℃; for 12h;

DOI:10.1016/j.ejmech.2011.04.013

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → 1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide (1313027-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / water

2.1: hydrazine hydrate

3.1: ethanol

3.2: 12 h / 60 °C

With hydrazine hydrate; potassium hydroxide; In ethanol; water;

DOI:10.1016/j.ejmech.2011.04.013

Reference yield:

cyclohexylthiocarbamoylsulfanyl-acetic acid (112864-51-4) → 1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide (1313027-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate

2.1: ethanol

2.2: 12 h / 60 °C

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.ejmech.2011.04.013

upstream raw materials:

cyclohexylamine

4-cyclohexyl-thiosemicarbazide

2,8-dichloroquinoline-3-carbaldehyde

cyclohexylthiocarbamoylsulfanyl-acetic acid

Downstream raw materials:

N-(4-acetyl-5-(2,8-dichloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide