Technology Process of 3-(2,5-dimethoxybenzyl)-3H-imidazo[4,5-c]pyridine
There total 4 articles about 3-(2,5-dimethoxybenzyl)-3H-imidazo[4,5-c]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate;
In
tert-butyl alcohol;
at 110 ℃;
for 6.5h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/jo500064j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere; Schlenk technique
1.2: 14 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere; Schlenk technique
3.1: potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex / tert-butyl alcohol / 6.5 h / 110 °C / Schlenk technique; Inert atmosphere
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; sodium hydride; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
DOI:10.1021/jo500064j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere; Schlenk technique
1.2: 14 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere; Schlenk technique
3.1: potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex / tert-butyl alcohol / 6.5 h / 110 °C / Schlenk technique; Inert atmosphere
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; sodium hydride; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
DOI:10.1021/jo500064j