(3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

Base Information

Chemical Name:(3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal
CAS No.:1187819-79-9
Molecular Formula:C₂₄H₃₄O₃Si
Molecular Weight:398.618
Hs Code.:

Synonyms:(3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

Chemical Property:

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Technology Process of (3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

There total 6 articles about (3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1187819-84-6
(S)-5-(4-(benzyloxy)phenyl)-3-(tert-butyldimethylsilyloxy)pentan-1-ol

: 1187819-79-9
(3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

Guidance literature:: With sodium periodate; In tetrahydrofuran; water; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1002/hlca.201500073

Reference yield:

: 1638640-04-6
({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane

: 1187819-79-9
(3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

Guidance literature:: Multi-step reaction with 2 steps

1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / acetone; water / 5 h / 25 °C / Inert atmosphere

2: sodium periodate / water; tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

With sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetone;
DOI:10.1002/hlca.201500073

Reference yield:

: 87030-11-3
ethyl 3-(4-(benzyloxy)phenyl)acrylate

: 1187819-79-9
(3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

Guidance literature:: Multi-step reaction with 6 steps

1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; toluene / -70 °C / Inert atmosphere

3: diethyl ether; pentane / 20 h / -78 °C / Inert atmosphere

4: 1H-imidazole / dichloromethane / 24 h / 0 - 20 °C

5: osmium(VIII) oxide; 4-methylmorpholine N-oxide / acetone; water / 5 h / 25 °C / Inert atmosphere

6: sodium periodate / water; tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; nickel(II) chloride hexahydrate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; toluene; pentane;
DOI:10.1002/hlca.201500073