({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane

Base Information

• Chemical Name: ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane
• CAS No.: 1638640-04-6
• Molecular Formula: C₂₅H₃₆O₂Si
• Molecular Weight: 396.645
• Mol file: 1638640-04-6.mol

Synonyms:({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane

Chemical Property of ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane

There total 12 articles about ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloro-2,3,3-trimethyl-butane (918-07-0) + (-)-(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-ol (767330-04-1) → ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane (1638640-04-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1002/hlca.201300221

Reference yield: 93.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (-)-(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-ol (767330-04-1) → ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane (1638640-04-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1002/hlca.201500073

Reference yield:

C18H18O3 (243641-03-4) → ({(3S)-1-[4-(benzyloxy)phenyl]hex-5-en-3-yl}oxy)(tert-butyl)(dimethyl)silane (1638640-04-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 0.02 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.17 h / -78 °C

3.1: D-Prolin / dimethyl sulfoxide / 0.5 h / 0 - 20 °C

3.2: 2 h / 20 °C

4.1: copper(ll) sulfate pentahydrate / methanol / 0 - 20 °C

5.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 4 h / 0 - 20 °C

6.1: potassium carbonate / methanol / 1 h / 20 °C

7.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

8.1: 1H-imidazole / dichloromethane / 4 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; copper(l) iodide; copper(ll) sulfate pentahydrate; nickel(II) chloride hexahydrate; diisobutylaluminium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; D-Prolin; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1002/hlca.201300221

upstream raw materials:

C₁₈H₁₈O₃

methyl 4-[4-(benzyloxy)phenyl]butanoate

4-(4-Benzyloxyphenyl)butanal

C₂₃H₂₅NO₃

Downstream raw materials:

C₂₅H₃₆O₃Si

{(1S)-3-[4-(benzyloxy)phenyl]-1-{[(2S)-oxiran-2-yl]methyl}propoxy}(tert-butyl)dimethylsilane

(3S,5R)-1-(4-hydroxyphenyl)nonadecane-3,5-diol

(3S,5S)-3,5-dihydroxy-1-(4-hydroxyphenyl)-7-phenyl-6E-heptane