(4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol

Base Information

Chemical Name:(4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol
CAS No.:1187819-78-8
Molecular Formula:C₂₇H₄₀O₃Si
Molecular Weight:440.698
Hs Code.:

Synonyms:(4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol

Chemical Property:

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Technology Process of (4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol

There total 2 articles about (4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187819-79-9
(3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal

: 1730-25-2
allylmagnesium bromide

: 1187819-78-8
(4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol

: (4S,6S)-8-(4-(benzyloxy)phenyl)-6-(tert-butyldimethylsilyloxy)oct-1-en-4-ol

Guidance literature:: (3S)-5-[4-(benzyloxy)phenyl]-3-{[tert-butyl(dimethyl)silyl]oxy}pentanal; allylmagnesium bromide; In diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

With ammonium chloride; In diethyl ether; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tetasy.2009.05.036

Reference yield:

: 1258516-47-0
{(1S)-3-[4-(benzyloxy)phenyl]-1-{[(2S)-oxiran-2-yl]methyl}propoxy}(tert-butyl)dimethylsilane

: 1826-67-1
vinyl magnesium bromide

: 1187819-78-8
(4R,6S)-8-[4-(benzyloxy)phenyl]-6-{[(tert-butyl)dimethylsilyl]oxy}oct-1-en-4-ol

: (4S,6S)-8-(4-(benzyloxy)phenyl)-6-(tert-butyldimethylsilyloxy)oct-1-en-4-ol

Guidance literature:: With 1H-imidazole; In diethyl ether; at 0 ℃; for 1.5h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/hlca.200900478